Rifampicin susc … The use of antibiotics effective against anaerobic bacteria may be necessary for patients with potentially fatal aspiration pneumonia. 2020 Oct 28;9(11):3477. doi: 10.3390/jcm9113477. Aspiration pneumonia. This rapid review aims to assess the effectiveness of regimens containing antibiotic coverage for atypical pathogens compared with regimens containing antibiotic coverage for typical pathogens. HHS Epub 2009 Feb 6. Merrem Hospital-Acquired Pneumonia Study Group. The results suggest that cefiderocol is a potential option for the treatment of patients with nosocomial pneumonia, including those caused by multidrug-resistant Gram-negative bacteria. Levofloxacin in the treatment of ventilator-associated pneumonia. In patients with ventilator-associated pneumonia, a satisfactory clinical response was observed in 68% at the end of treatment and 63% at follow-up. J Chemother. Eur Stroke J. Methods: Reappraisal of clindamycin IV monotherapy for treatment of mild-to-moderate aspiration pneumonia in elderly patients. Results: eCollection 2013. 2019 Dec 23;19(1):260. doi: 10.1186/s12890-019-1021-5. Recognizing and managing a potentially growing disorder. The overall clinical efficacy rate of meropenem therapy (1.0 g/day) was 61.3%. Objective and background: The antibacterial activities of imipenem-cilastatin, meropenem-cilastatin, cefepime and ceftazidime against Enterobacter cloacae NOR-1, which produces the carbapenem-hydrolyzing beta-lactamase NmcA and a cephalosporinase, and against one of its in vitro-obtained ceftazidime-resistant mutant were compared by using an experimental model of pneumonia with immunocompetent rats. Please enable it to take advantage of the complete set of features!  |  Cefiderocol was non-inferior to high-dose, extended-infusion meropenem in terms of all-cause mortality on day 14 in patients with Gram-negative nosocomial pneumonia, with similar tolerability. Clipboard, Search History, and several other advanced features are temporarily unavailable. Ventilator-associated pneumonia: monotherapy is optimal if chosen wisely. Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. This site needs JavaScript to work properly. Conclusion: Get the latest research from NIH: https://www.nih.gov/coronavirus. The secondary aim of the study was to compare the results of routinely testings and those obtained by a referent laboratory. The abstract, “Efficacy and Safety of Cefiderocol versus High-Dose Meropenem in Patients with Nosocomial Pneumonia — Results of a Phase 3 Randomized, Multicenter, Double-Blind, Non-Inferiority Study,” was presented in a late breaking oral abstract session … Aim: To compare the clinical efficacy and safety of cefepime and meropenem in patients with moderate-to-severe aspiration pneumonia. Alvarez-Lerma F, Grau S, Alvarez-Beltrán M. Clin Microbiol Infect. Clinical Need and Target Population Community-acquired pneumonia (CAP) is a common condition worldwide that can sometimes lead to hospitalization. Please enable it to take advantage of the complete set of features! The mortality rate was 9.7%, and anaerobic bacteria coexisted with aerobic bacteria in 66.7% of the patients who died. Includes dosages for Skin and Structure Infection, Intraabdominal Infection, Nosocomial Pneumonia and more; plus renal, liver and dialysis adjustments. Misschien heeft u hem later weer nodig. 2005 Apr;127(4):1276-82. doi: 10.1378/chest.127.4.1276. 2006 May;12 Suppl 3:81-92. doi: 10.1111/j.1469-0691.2006.01399.x. When disease severity was classified according to the Japanese Respiratory Society (JRS) guidelines, 80.7% of the cases in this study were graded as "most severe". 2013 Sep 2;8(9):e73396. [Diagnosis and therapy of aspiration pneumonia]. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Hamao N, Ito I, Konishi S, Tanabe N, Shirata M, Oi I, Tsukino M, Matsumoto H, Yasutomo Y, Kadowaki S, Hirai T. BMC Pulm Med. Lorente L, Lorenzo L, Martín MM, Jiménez A, Mora ML. Aspiration pneumonitis follows the aspiration of gastric contents, ... meropenem (88%) vs. clindamycin plus gentamicin (90%). Of 255 patients enrolled, 111 were evaluable for efficacy, including 60 patients with ventilator-associated pneumonia. Of 255 patients enrolled, 111 were eva … Culture, gram strain of tracheal aspirate or lavage fluid should be performed in all cases of suspected VAP. Meropenem by continuous versus intermittent infusion in ventilator-associated pneumonia due to gram-negative bacilli. Patients from 28 centers in the USA received meropenem 1 g every 8 h intravenously. Chest. Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial. Antibiotics for Aspiration Pneumonia in Neurologically Impaired Children. Meropenem is indicated for the treatment of complicated intra-abdominal infections caused by E. coli, Klebsiella pneumoniae, P. aeruginosa, B. fragilis, Bacteroides thetaiotaomicron, and Peptostreptococcus species , at a dosage of 1 g every 8 h for adults and 20 mg/kg every 8 h (to a maximum of 1 g) for children, infused over 15–30 min (or administered by bolus injection over 3–5 … excellent anaerobic coverage for aspiration pneumonia. pneumonia, intra-abdominal infection, gynecologic infection, ... clindamycin, or moxifloxacin provide excellent anaerobic coverage for aspiration pneumonia. USA.gov. Comparison of the Effects of Sugammadex, Neostigmine, and Pyridostigmine on Postoperative Nausea and Vomiting: A Propensity Matched Study of Five Hospitals. Treatment guidelines for aspiration pneumonia recommend the use of antibiotics effective against anaerobic bacteria, such as carbapenems. Bartoloni A, Strohmeyer M, Corti G, Buonomini MI, Franchino L, Romanelli G, Moretti AM, De Vizzi GB, Petraglia A, Mancini P, Atzeni R, Fogliani V, Giura R, Paradisi F. Semin Respir Crit Care Med. The causative organisms of aspiration pneumonia, including anaerobic bacteria, were investigated using fiberoptic bronchoscopy. Most of the adverse event drug discontinuations were a result of fatal adverse events and not because of decisions made by researchers, which occurred in 24 of 37 cases in the combination group and 28 of 31 cases in the meropenem group where patients … Efficacy of meropenem as monotherapy in the treatment of ventilator-associated pneumonia. S. pneumoniae is enclosed in a complex polysaccharide capsule that can be used to classify strains into serotypes. The intent-to-treat population consisted of 726 patients who were randomly assigned to receive either a 3-g combination of 2 g ceftolozane and 1 g tazobactam (n=362) or 1 g meropenem (n=364); both groups were administered their respective treatments as 1-hour infusions every 8 hours for 8 to 14 days.  |  Methods. The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem. In this open-label, randomized study, either cefepime 1 g or meropenem 0.5 g was administered intravenously every 8 h to patients with moderate-to-severe community-acquired or nursing-home acquired pneumonia at risk for aspiration for an average of 10.5 days. In this randomized, phase 3, non-inferiority trial, adults aged 18 years or older with hospital-acquired, ventilator- or, healthcare-associated Gram-negative pneumonia were enrolled. By continuing to browse this site you are agreeing to our use of cookies. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Ann Pharmacother. Secher T, Fas S, Fauconnier L, Mathieu M, Rutschi O, Ryffel B, Rudolf M. PLoS One. NLM So far, at least 92 structurally and serologically distinct serotypes have been recognized (). 1999 Jan;115(1):178-83. doi: 10.1378/chest.115.1.178. Epub 2013 Jan 24. COVID-19 is an emerging, rapidly evolving situation. NIH Misschien heeft u hem later weer nodig. Epub 2006 Jan 31. 2020 Jun 5;20(1):160. doi: 10.1186/s12890-020-01198-4. Cefiderocol was non-inferior to high-dose, extended infusion meropenem in patients with Gram-negative nosocomial pneumonia, according to a study published in The Lancet Infectious Diseases.. Multicenter randomized trial comparing meropenem (1.5 g daily) and imipenem/cilastatin (2 g daily) in the hospital treatment of community-acquired pneumonia.  |  National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. A prospective study of 62 elderly hospitalized patients with aspiration pneumonia (34 males, 28 females; mean age 86.6 years) was conducted. They exhibit low minimum inhibitory concentrations on organisms like methicillin-susceptible S. aureus, S. pyogenes, and S. pneumoniae. No fetal toxicity or malformations were observed in pregnant rats and Cynomolgus monkeys administered intravenous meropenem during organogenesis at doses up to 2.4 and 2.3 times the maximum recommended human dose (MRHD) based on body surface area comparison, respectively; in rats administered intravenous meropenem in late pregnancy and during lactation period, there were no … 2019 Dec;4(4):318-328. doi: 10.1177/2396987319851335. However, the utility of “continued double-coverage” (after susceptibilities identified) is a long-standing point of controversy – some experts recommend this for serious infections including bacteremia in neutropenic patients, endocarditis, meningitis, and possibly pneumonia. Dynamics of microbiota during mechanical ventilation in aspiration pneumonia. 2013 Apr;19(2):291-8. doi: 10.1007/s10156-013-0552-6. 1000 mg, poeder voor oplossing voor injectie of infusie 1000 mg meropenem Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat gebruiken want er staat belangrijke informatie in voor u. Get the latest public health information from CDC: https://www.coronavirus.gov. •Conclusion: A regimen of 500mg IV q6h is able to achieve a similar probability of target attainment with Coverage for atypical organisms in patients with pneumonia, especially in the following situations: 1) Patients who are at some risk for community-acquired MRSA pneumonia, but not enough risk to justify addition of linezolid or vancomycin (doxycycline has fair activity against community-acquired MRSA, but lacks evidence for efficacy in MRSA pneumonia). Antibiotic treatment for pneumonia complicating stroke: Recommendations from the pneumonia in stroke consensus (PISCES) group. Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, J-STAGE, Japan Science and Technology Information Aggregator, Electronic.  |  Streptococcus pneumoniae is a common pathogen that causes various types of bacterial infections, such as pneumonia, otitis media, occult bacteremia, and meningitis (). NLM Prospective randomized comparison study of piperacillin/tazobactam and meropenem for healthcare-associated pneumonia in Japan. It is given by injection into a vein. The role of gram-negative bacteria in healthcare-associated pneumonia. INTRODUCTION  Community-acquired pneumonia (CAP) is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community, as distinguished from hospital-acquired (nosocomial) pneumonia (HAP). 2006;10(2):141. doi: 10.1186/cc4908. Effectiveness of meropenem for the treatment of aspiration pneumonia in elderly patients Intern Med. Yamamoto Y, Izumikawa K, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Tsukamoto M, Kakeya H, Yanagihara K, Yasuoka A, Kohno S. J Infect Chemother. Aspiration ... meropenem (88%) vs. clindamycin plus gentamicin (90%). • Broncho-pulmonary infections in cystic fibrosis • … In Japan, an increase in the elderly population is associated with an increased incidence of aspiration pneumonia. Meropenem is indicated for the treatment of the following infections in adults and children aged 3 months and older (see sections 4.4 and 5.1): • Severe pneumonia, including hospital and ventilator-associated pneumonia. This study demonstrates that meropenem monotherapy is effective and well tolerated for patients with hospital-acquired pneumonia, including a subgroup of patients with ventilator-associated pneumonia. This site needs JavaScript to work properly. doi: 10.1371/journal.pone.0073396. Kadowaki M, Demura Y, Mizuno S, Uesaka D, Ameshima S, Miyamori I, Ishizaki T. Chest. 2009;48(3):129-35. doi: 10.2169/internalmedicine.48.1308. The overall detection rate of bacteria was 87.1% (monomicrobial, 32.3%; polymicrobial, 54.8%). NIH Meropenem Target Attainment vs. P. aeruginosa •Probability of target attainment is similar for doses of 1g IV q8h and 500mg IV q6h (both at the desired probability of ≥90%), up to an MIC of 2 mg/L. In addition, the efficacy and safety of intravenous meropenem for this treatment of this condition were evaluated. The role of anaerobes in patients with ventilator-associated pneumonia and aspiration pneumonia: a prospective study. The efficacy and tolerability of meropenem as empirical treatment in patients with hospital-acquired pneumonia was determined in a prospective, open-label, non-randomized trial. - Bewaar deze bijsluiter.  |  {{configCtrl2.info.metaDescription}} This site uses cookies. Dtsch Med Wochenschr. 2003 Mar;113(3):99-102, 105-6, 111-2. doi: 10.3810/pgm.2003.03.1390. Clipboard, Search History, and several other advanced features are temporarily unavailable. At end of treatment 74% of patients had a satisfactory clinical response and 64% had this response at follow-up, which could last up to 28 days after treatment. 2020 Jul 1;15(7):395-402. doi: 10.12788/jhm.3338. 2001 Feb;13(1):70-81. doi: 10.1179/joc.2001.13.1.70. Epub 2019 May 27. Postgrad Med. The overall satisfactory response rate for individual pretreatment pathogens ranged from 65% to 100%. In-vitro susceptibility of 299 Neisseria meningitidis and 157 Streptococcus pneumoniae strains from meningitis patients in The Netherlands in 1993 and 1994 to meropenem was determined using the Etest. KEY POINTS Meropenem (Merrem) is an injectable carbapenem and beta-lactam antibiotic that interferes with bacterial cell wall synthesis in sensitive organisms Has activity versus a wide array of organisms, including multi-drug resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae DOES NOT cover MRSA or VRE Carbapenems like meropenem are generally considered … USA.gov. Toepassing komt met name in aanmerking bij ernstige abdominale infecties en bij neutropene patiënten. Susceptibility to penicillin, ceftriaxone, and chloramphenicol was also determined. The microbiologic eradication rate was also However, the effectiveness of cefepime in aspiration pneumonia has not yet been evaluated. Background Current guidelines of empirical antibiotic treatment for inpatients with community-acquired pneumonia recommend antibiotics whose spectrum covers intracellular (atypical) pathogens. Crit Care. - Bewaar deze bijsluiter. Meronem i.v. Thomson J, Hall M, Ambroggio L, Berry JG, Stone B, Srivastava R, Shah SS. Kim JH, Lim MS, Choi JW, Kim H, Kwon YS, Lee JJ. However, the role of anaerobic bacteria in aspiration pneumonia and the clinical efficacy of meropenem in elderly aspiration pneumonia patients have only begun to be investigated. In het algemeen: Toepassing van meropenem dient te worden gereserveerd voor ernstige infecties waarbij penicillinen of cefalosporinen onvoldoende effectief zijn. Of the 111 pathogens detected (14 anaerobic pathogens remained unidentified), anaerobic bacteria accounted for 19.8% and gram-negative enteric bacilli made up 19.8%. Background: Treatment of aspiration pneumonia is an important problem due to aging of populations worldwide. Meropenem Fresenius Kabi 500 mg poeder voor oplossing voor injectie of infusie Meropenem Fresenius Kabi 1 g poeder voor oplossing voor injectie of infusie Meropenem Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat gebruiken want er staat belangrijke informatie in voor u. Meropenem Antibiotic Class: Carbapenem Antimicrobial Spectrum: Aerobic gram-positive microorganisms: S. aureus including penicillinase-producing strains, Group D streptococcus including Enterococcus spp., Streptococcus pneumoniae, S. pyogenes, S. viridans group Adults with nosocomial pneumonia (including ventilator-associated pneumonia), enrolled at 136 centres in 23 countries, were randomly assigned (1:1) to 2000 mg ceftazidime and 500 mg avibactam (by 2 h intravenous infusion every 8 h) or 1000 mg meropenem (by 30-min intravenous infusion every 8 h) for 7–14 days; regimens were adjusted for renal function. Meropenem therapy for aspiration pneumonia is clinically effective and tolerable in elderly patients. Otsuji K, Fukuda K, Ogawa M, Fujino Y, Kamochi M, Saito M. BMC Pulm Med. Get the latest public health information from CDC: https://www.coronavirus.gov. Alvarez Lerma F; Serious Infection Study Group. They have poor coverage of MRSA and enterococcal infections because of their aforementioned intrinsic resistance. meropenem vergelijken met een ander geneesmiddel.. Advies. COVID-19 is an emerging, rapidly evolving situation. Kishore AK, Jeans AR, Garau J, Bustamante A, Kalra L, Langhorne P, Chamorro A, Urra X, Katan M, Napoli MD, Westendorp W, Nederkoorn PJ, van de Beek D, Roffe C, Woodhead M, Montaner J, Meisel A, Smith CJ.  |  J Hosp Med. 2009 Feb;30(1):61-6. doi: 10.1055/s-0028-1119810. Combination and meropenem treatments also showed comparable numbers of reported adverse events, 85.9% and 83.3%, respectively. No sufficient evidence exists to support the necessity of such coverage, whereas limiting it may reduce toxic effects, resistance, and expense. Get the latest research from NIH: https://www.nih.gov/coronavirus. Patients from 28 centers in the USA received meropenem 1 g every 8 h intravenously. The efficacy and tolerability of meropenem as empirical treatment in patients with hospital-acquired pneumonia was determined in a prospective, open-label, non-randomized trial. Detailed Meropenem dosage information for adults and children. Meropenem is a carbapenem that has an excellent activity against many gram-positive and gram-negative aerobic, ... pneumonia (29%), peritonitis (12%) and wound infections (3%), in 15 French hospitals in 2006. APEKS-NP was a multicenter, double-blind, parallel-group trial that compared the all-cause mortality of cefiderocol at Day 14 to high-dose meropenem in 300 adults with nosocomial pneumonia. 2006 Mar 24;131(12):624-8. doi: 10.1055/s-2006-933707. 2006 Feb;40(2):219-23. doi: 10.1345/aph.1G467. Epub 2019 Nov 20. Meropenem therapy for aspiration pneumonia is clinically effective and tolerable in elderly patients. The microbiologic eradication rate was also high, with a median of over 90% (range 88-100%). J Clin Med. Gram-Positive Coverage 1,2 Generally, carbapenems work against various Gram-positive bacteria. 500 mg, poeder voor oplossing voor injectie of infusie 500 mg Meronem i.v. HHS
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